从突触重塑到胶质交互，高效科研抗体让抑郁神经环路“显形”

       抑郁症(major depressive disorder, MDD)是一种常见的复杂神经精神疾病，以持续性的情绪低落、兴趣减退、认知功能障碍和生理失调为核心特征。重度抑郁症已经成为一大致残诱因，具有较高的发病率和死亡率。现代医学将其定义为“生物-心理-社会”多因素交互作用的结果。

       目前广泛接受的MDD发病机制理论包括：神经递质与受体假说、下丘脑-垂体-肾上腺(HPA)轴假说、炎症因子假说、神经可塑性假说等。其发病机制已从传统的单胺递质假说拓展至神经环路、胶质细胞、免疫代谢等多维度模型。但这些假说均无法全面解释MDD的病理机制，甚至难以仅用单一假说完整阐明其发病机理。

图1. MDD病理机制假说

参考来源：Signal Transduct Target Ther. 2024 Feb 9;9(1):30.

       三环类抗抑郁药(TCAs)、选择性5-HT再摄取抑制剂(SSRIs)以及5-HT和SNRIs等是临床常用的MDD治疗药物，它们通过多种分子机制发挥效用以改善抑郁症状。如TCAs、SSRIs和SNRIs都能抑制5-HT转运体(SERTs)对5-HT的再摄取，特别是SSRIs对SERTs具有选择性抑制作用，这会增加突触间隙中5-HT的浓度，并通过作用于突触后膜上的5-HT受体(5-HTRs)发挥抗抑郁作用，同时激活cAMP-PKA通路。

图2. 抗抑郁药物的分子机制图

参考来源：Signal Transduct Target Ther. 2024 Feb 9;9(1):30.

识别MDD生物标志物对于阐明其发病机制、疾病诊断及治疗等至关重要，为了支持您的MDD研究，我们梳理了一份靶向MDD关键靶点的畅销抗体清单，并有多篇文献数据支持。

部分高分文献展示

1.bs-0199R | GFAP Rabbit pAb | IF

[IF=32.086] Yuxin Liu. et al. Ferromagnetic flexible electronics for brain-wide selective neural recording. ADV MATER. 2022 Nov;:2208251

2.bsm-33207M | TNF alpha Rabbit pAb | IF

[IF=32.086] Yingying Jin. et al. A Novel “Inside-Out” Intraocular Nanomedicine Delivery Mode for Nanomaterials Biological Effects Enhanced Choroidal Neovascularization Occlusion and Microenvironment Regulation. ADV MATER. 2022 Dec;:2209690

3.bs-0480R | IFN gamma Rabbit pAb | IHC

[IF=27.7] Yang Liu. et al.Generation of tolerogenic antigen-presenting cells in vivo via the delivery of mRNA encoding PDL1 within lipid nanoparticles..Nature Biomedical Engineering.2025 Mar 28.

4.bs-4989R | BDNF Rabbit pAb | IF

[IF=16.744] Xiaoyu Ma. et al. Multifunctional injectable hydrogel promotes functional recovery after stroke by modulating microglial polarization, angiogenesis and neuroplasticity. CHEM ENG J. 2023 May;464:142520

5.bs-0199R | GFAP Rabbit pAb | WB, IF, IHC

[IF=13.3] Fangyu Qiao. et al. Dual siRNA-Loaded Cell Membrane Functionalized Matrix Facilitates Bone Regeneration with Angiogenesis and Neurogenesis. SMALL. 2023 Oct;:2307062

6.bsm-52259R | ERK1/2 Recombinant Rabbit mAb | WB

[IF=8.2] Minghao Yan. et al. Screening, identification and functional validation of Microcystin-LR direct binding target proteins based on thermal proteomics profiling. SCI TOTAL ENVIRON. 2025 Jan;958:178047

7.bsm-52727R | IL-1 beta Recombinant Rabbit mAb | WB

[IF=8.2] Lin Peng. et al. Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155/TRAF3/ROS pathway. INT J BIOL MACROMOL. 2023 Dec;253:127501